The two legs will take place on 13th and 20th April, respectively. Schalke will play the first leg away from home at the Amsterdam ArenA. Both matches will kick off at 21:05 CEST.
The Europa League quarter final draw in full:
RSC Anderlecht vs. Manchester United
Celta Vigo vs. KRC Genk
Ajax Amsterdam vs. FC Schalke 04
Olympique Lyon vs. Besiktas Istanbul.